Cytoskeletal Organization and Rb Tumor Suppressor Gene
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Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.
The neurofibromatosis 2 ( NF2 ) gene product, merlin, is a tumor suppressor protein mutated in schwanno-mas and several other tumors. Merlin, which shares significant homology with the actin-associated proteins ezrin, radixin and moesin (ERM proteins), inhibits cell growth when overexpressed in cell lines. The similarities between merlin and ERM proteins suggest that merlin's growth-regulatory ...
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